Isolated Aspergillosis of the Brain in an Immunocompetent Patient: A Case Report

Aspergillosis involving central nervous system (CNS) is known to occur frequently in the immunocompromised individual owing to increased invasive feature of the disease and decreased host defense capacity(1, 2). The common pathway of CNS aspergillosis is hematogenous dissemination usually from lung or continuous extension from adjacent structures such as sinonasal cavity (3, 4). Therefore, the radiologic findings of isolated aspergillosis in immunocompetent patient have been rarely described in the published literature (5, 6). We report an interesting case of a 29-year-old male without any known medical history who presented with fever and intractable headache. Isolated brain lesion was found in subsequent imaging studies which were pathologically confirmed as aspergillosis.